...Can somebody PLEASE tell me HOW in the world can I beat the Big Sister?!?
The first Big Daddy that you meet in the game, I was able to take him out easily (probably 'cuz after playing BioShock no less than seven times it had become old hat and I not only knew the tricks but was able to adapt BioShock 2's new weapons to those tactics). And I've got my first Little Sister to harvest the ADAM (which took considerably longer 'cuz those Splicers were coming at us like there was no tomorrow).
Well, I've been stuck in the museum for several hours now because of that Big Sister. She is whipping my butt like no nemesis I've ever fought in a video game.
So I'm putting the call out to anyone who's gotten lucky. All I'm asking is for the best strategy to taking out the Big Sister. Nothing more than that.
If you've gotten past this... thing, feel free to post how you dunnit as a comment :-)